Robust reconstruction of the rate constant distribution using the phase function method.

ABSTRACT: Many biological processes exhibit complex kinetic behavior that involves a nontrivial distribution of rate constants. Characterization of the rate constant distribution is often critical for mechanistic understandings of these processes. However, it is difficult to extract a rate constant distribution from data measured in the time domain. This is due to the numerical instability of the inverse Laplace transform, a long-standing mathematical challenge that has hampered data analysis in many disciplines. Here, we present a method that allows us to reconstruct the probability distribution of rate constants from decay data in the time domain, without fitting to specific trial functions or requiring any prior knowledge of the rate distribution. The robustness (numerical stability) of this reco

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC1635682 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature