Multiple, non-allelic, intein-coding sequences in eukaryotic RNA polymerase genes.

ABSTRACT:

Background

Inteins are self-splicing protein elements. They are translated as inserts within host proteins that excise themselves and ligate the flanking portions of the host protein (exteins) with a peptide bond. They are encoded as in-frame insertions within the genes for the host proteins. Inteins are found in all three domains of life and in viruses, but have a very sporadic distribution. Only a small number of intein coding sequences have been identified in eukaryotic nuclear genes, and all of these are from ascomycete or basidiomycete fungi.

Results

We identified seven intein coding sequences within nuclear genes coding for the second largest subunits of RNA polymerase. These sequences were found in diverse eukaryotes: one is in the second largest subunit of RNA polyme

SUBMITTER: Goodwin TJ 

PROVIDER: S-EPMC1635734 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature