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A high-resolution single nucleotide polymorphism genetic map of the mouse genome.

ABSTRACT: High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans. Using more than 10,000 single nucleotide polymorphisms evenly spaced across the mouse genome, we have constructed genetic maps for both outbred and inbred mice, and separately for males and females. Recombination rates are highly correlated in outbred and inbred mice, but show relatively low correlation between males and females. Differences between male and female recombination maps and the sequence features associated with recombination are strikingly similar to those observed in humans. Genetic maps are available from http://gscan.well.ox.ac.uk/#genetic_map and as supporting information to this publication.

SUBMITTER: Shifman S

PROVIDER: S-EPMC1635748 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature

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A high-resolution single nucleotide polymorphism genetic map of the mouse genome.

Shifman Sagiv S Bell Jordana Tzenova JT Copley Richard R RR Taylor Martin S MS Williams Robert W RW Mott Richard R Flint Jonathan J

PLoS biology 20061101 12

High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans. Using more than 10,000 single nucleotide polymorphisms evenly spaced across the mouse genome, we have constructed genetic maps for both outbred and inbred mice, and separately for males and females. Recombination rates are highly correlated in outbred and inbred mice, but show relatively low correlation bet ...[more]

PMID: 17105354

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