Xtn3 is a developmentally expressed cardiac and skeletal muscle-specific novex-3 titin isoform.

ABSTRACT: Titin proteins play an essential role in maintaining muscle function and structure. Recent work has implicated the involvement of the novex-3 titin isoform in sarcomere restructuring and disease. Unlike avian and mammalian systems, Xenopus laevis myogenesis is characterized by a wave of primary myogenesis followed by apoptosis of the primary muscles and formation of new muscles by secondary myogenesis. We show here that the Xenopus laevis novex-3 titin isoform (Xtn3) is developmentally expressed throughout the somites, heart, and primary muscles of the developing embryo. Downregulation of Xtn3 expression at tadpole stages appears to coincide with the change in myofiber composition from solely embryonic "fast" fiber types to myofibers containing both "fast" and "slow" fiber types. We demons

SUBMITTER: Brown DD 

PROVIDER: S-EPMC1635806 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature