The immune-body cytokine network defines a social architecture of cell interactions.

ABSTRACT:

Background

Three networks of intercellular communication can be associated with cytokine secretion; one limited to cells of the immune system (immune cells), one limited to parenchymal cells of organs and tissues (body cells), and one involving interactions between immune and body cells (immune-body interface). These cytokine connections determine the inflammatory response to injury and subsequent healing as well as the biologic consequences of the adaptive immune response to antigens. We informatically probed the cytokine database to uncover the underlying network architecture of the three networks.

Results

We now report that the three cytokine networks are among the densest of complex networks yet studied, and each features a characteristic profile of specific three-cell m

SUBMITTER: Frankenstein Z 

PROVIDER: S-EPMC1636025 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature