ProFAT: a web-based tool for the functional annotation of protein sequences.

ABSTRACT:

Background

The functional annotation of proteins relies on published information concerning their close and remote homologues in sequence databases. Evidence for remote sequence similarity can be further strengthened by a similar biological background of the query sequence and identified database sequences. However, few tools exist so far, that provide a means to include functional information in sequence database searches.

Results

We present ProFAT, a web-based tool for the functional annotation of protein sequences based on remote sequence similarity. ProFAT combines sensitive sequence database search methods and a fold recognition algorithm with a simple text-mining approach. ProFAT extracts identified hits based on their biological background by keyword-mining of annotat

SUBMITTER: Bradshaw CR 

PROVIDER: S-EPMC1636073 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature