Systematic identification of pseudogenes through whole genome expression evidence profiling.

ABSTRACT: The identification of pseudogenes is an integral and significant part of the genome annotation because of their abundance and their impact on the experimental analysis of functional genes. Most of the computational annotation systems are not optimized for systematic pseudogene recognition, often annotating pseudogenes as functional genes, and users then propagate these errors to subsequent analyses and interpretations. In order to validate gene annotations and to identify pseudogenes that are potentially mis-annotated, we developed a novel approach based on whole genome profiling of existing transcript and protein sequences. This method has two important features: (i) equally detects both processed and non-processed pseudogenes and (ii) can identify transcribed pseudogenes. Applying this m

SUBMITTER: Yao A 

PROVIDER: S-EPMC1636364 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature