Comprehensive identification of Drosophila dorsal-ventral patterning genes using a whole-genome tiling array.

ABSTRACT: Dorsal-ventral (DV) patterning of the Drosophila embryo is initiated by Dorsal, a sequence-specific transcription factor distributed in a broad nuclear gradient in the precellular embryo. Previous studies have identified as many as 70 protein-coding genes and one microRNA (miRNA) gene that are directly or indirectly regulated by this gradient. A gene regulation network, or circuit diagram, including the functional interconnections among 40 Dorsal target genes and 20 associated tissue-specific enhancers, has been determined for the initial stages of gastrulation. Here, we attempt to extend this analysis by identifying additional DV patterning genes using a recently developed whole-genome tiling array. This analysis led to the identification of another 30 protein-coding genes, including the

SUBMITTER: Biemar F 

PROVIDER: S-EPMC1636694 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature