Fronto-cerebellar systems are associated with infant motor and adult executive functions in healthy adults but not in schizophrenia.

ABSTRACT: Delineating longitudinal relationships between early developmental markers, adult cognitive function, and adult brain structure could clarify the pathogenesis of neurodevelopmental disorders such as schizophrenia. We aimed to identify brain structural correlates of infant motor development (IMD) and adult executive function in nonpsychotic adults and to test for abnormal associations between these measures in people with schizophrenia. Representative samples of nonpsychotic adults (n = 93) and people with schizophrenia (n = 49) were drawn from the Northern Finland 1966 general population birth cohort. IMD was prospectively assessed at age 1 year; executive function testing and MRI were completed at age 33-35 years. We found that earlier motor development in infancy was correlated with supe

SUBMITTER: Ridler K 

PROVIDER: S-EPMC1636802 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature