Heterogeneity and temporal dynamics of evolution of G1 human rotaviruses in a settled population.

ABSTRACT: A rotavirus sample collection from 19 consecutive years was used to investigate the heterogeneity and the dynamics of evolution of G1 rotavirus strains in a geographically defined population. Phylogenetic analysis of the VP7 gene sequences of G1P[8] human rotavirus strains showed the circulation of a heterogeneous population comprising three lineages and seven sublineages. Increases in the circulation of G1 rotaviruses were apparently associated with the introduction of novel G1 strains that exhibited multiple amino acid changes in antigenic regions involved in rotavirus neutralization compared to the strains circulating in the previous years. The emergence and/or introduction of G1 antigenic variants might be responsible for the continuous circulation of G1 rotaviruses in the local popula

SUBMITTER: Arista S 

PROVIDER: S-EPMC1641777 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature