Recombination and selection in the evolution of picornaviruses and other Mammalian positive-stranded RNA viruses.

ABSTRACT: Picornaviridae are a large virus family causing widespread, often pathogenic infections in humans and other mammals. Picornaviruses are genetically and antigenically highly diverse, with evidence for complex evolutionary histories in which recombination plays a major part. To investigate the nature of recombination and selection processes underlying the evolution of serotypes within different picornavirus genera, large-scale analysis of recombination frequencies and sites, segregation by serotype within each genus, and sequence selection and composition was performed, and results were compared with those for other nonenveloped positive-stranded viruses (astroviruses and human noroviruses) and with flavivirus and alphavirus control groups. Enteroviruses, aphthoviruses, and teschoviruses sho

SUBMITTER: Simmonds P 

PROVIDER: S-EPMC1642140 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature