Structural insight into the antibiotic action of telithromycin against resistant mutants.

ABSTRACT: The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.

SUBMITTER: Berisio R 

PROVIDER: S-EPMC164882 | biostudies-literature | 2003 Jul

REPOSITORIES: biostudies-literature