Analysis of the XRCC1 gene as a modifier of the cerebral response in ischemic stroke.

ABSTRACT:

Background

Although there have been studies of the genetic risk factors in the development of stroke, there have been few investigations of role of genes in the cerebral response to ischemia. The brain responds to ischemia in a series of reactions that ultimately influence the volume of a stroke that, in general, correlates with disability. We hypothesize that polymorphisms in genes encoding proteins involved in these reactions could act as modifiers of this response and impact stroke volume. One of the pathways participating in the cerebral ischemic response involves reactive oxygen species which can cause oxidative damage to nucleic acids. DNA repair mechanisms are in place to protect against such damage and imply a role for DNA repair genes in the response of the brain to ischem

SUBMITTER: Dutra AV 

PROVIDER: S-EPMC1654138 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature