Tracing the origin of functional and conserved domains in the human proteome: implications for protein evolution at the modular level.

ABSTRACT:

Background

The functional repertoire of the human proteome is an incremental collection of functions accomplished by protein domains evolved along the Homo sapiens lineage. Therefore, knowledge on the origin of these functionalities provides a better understanding of the domain and protein evolution in human. The lack of proper comprehension about such origin has impelled us to study the evolutionary origin of human proteome in a unique way as detailed in this study.

Results

This study reports a unique approach for understanding the evolution of human proteome by tracing the origin of its constituting domains hierarchically, along the Homo sapiens lineage. The uniqueness of this method lies in subtractive searching of functional and conserved domains in the human proteome re

SUBMITTER: Pal LR 

PROVIDER: S-EPMC1654190 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature