A novel BDNF gene promoter directs expression to skeletal muscle.

ABSTRACT:

Background

Cell-specific expression of the gene that encodes brain-derived neurotrophic factor (BDNF) is required for the normal development of peripheral sensory neurons and efficient synaptic transmission in the mature central and peripheral nervous system. The control of BDNF gene expression involves multiple tissue and cell-specific promoters that are differentially regulated. The molecular mechanisms that are responsible for tissue and cell-specific expression of these promoters are still incompletely understood.

Results

The cloning and analysis of three additional zebrafish (Danio rerio) BDNF gene exons and two associated promoters, is reported. Among them are two exons that generate a novel tripartite mature transcript. The exons were located on the transcription unit

SUBMITTER: Heinrich G 

PROVIDER: S-EPMC165605 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature