Treatment of polydrug-using opiate dependents during withdrawal: towards a standardisation of treatment.

ABSTRACT:

Background

The growing tendency among opioid addicts to misuse multiple other drugs should lead clinicians and researchers to search for new pharmacological strategies in order to prevent life-threatening complications and minimize withdrawal symptoms during polydrug detoxification.

Methods

A non-randomised, open-label in-patient detoxification study was used to compare the short-time efficacy of a standardised regimen comprising 6 days Buprenorphine and 10 days Valproate (BPN/VPA) (n = 12) to a control group (n = 50) who took a 10-day traditional Clonidine/Carbamazepine (CLN/CBZ) regimen. Sixty-two dependent subjects admitted to a detoxification unit were included, all dependent on at least opioids and benzodiazepines. Other dependencies were not excluded.

Results

In

SUBMITTER: Kristensen O 

PROVIDER: S-EPMC1660570 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature