The conserved protein kinase-A target motif in synapsin of Drosophila is effectively modified by pre-mRNA editing.

ABSTRACT:

Background

Synapsins are abundant synaptic vesicle associated phosphoproteins that are involved in the fine regulation of neurotransmitter release. The Drosophila member of this protein family contains three conserved domains (A, C, and E) and is expressed in most or all synaptic terminals. Similar to mouse mutants, synapsin knock-out flies show no obvious structural defects but are disturbed in complex behaviour, notably learning and memory.

Results

We demonstrate that the N-terminal phosphorylation consensus motif RRxS that is conserved in all synapsins investigated so far, is modified in Drosophila by pre-mRNA editing. In mammals this motif represents the target site P1 of protein kinase A (PKA) and calcium/calmodulin dependent protein kinase I/IV. The result of this edit

SUBMITTER: Diegelmann S 

PROVIDER: S-EPMC1660579 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature