Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells.

ABSTRACT: Hematopoietic cells have long been defined as round, nonpolar cells that show uniform distribution of cell surface-associated molecules. However, recent analyses of the immunological synapse and the importance of lipid microdomains in signaling have shed new light on the aspect of lymphocyte polarization during the activation processes, but none of the molecules implicated so far in either the activation process or the microdomain residency are known to have a preferential localization in nonactivated cells. Chemical crosslinking and fluorescence resonance energy transfer methods have allowed the visualization of certain glycosylphosphatidylinositol-anchored proteins in lipid rafts but so far no microdomain resident protein has been shown to exist as visible stable platforms in the membran

SUBMITTER: Rajendran L 

PROVIDER: S-EPMC166213 | biostudies-literature | 2003 Jul

REPOSITORIES: biostudies-literature