Evolutionary genomics of inversions in Drosophila pseudoobscura: evidence for epistasis.

ABSTRACT: Drosophila pseudoobscura harbors a rich polymorphism for paracentric inversions on the third chromosome, and the clines in the inversion frequencies across the southwestern United States indicate that strong natural selection operates on them. Isogenic inversion strains were made from isofemale lines collected from four localities, and eight molecular markers were mapped on the third chromosome. Nucleotide diversity was measured for these loci and formed the basis of an evolutionary genomic analysis. The loci were differentiated among inversions. The inversions did not show significant differences among populations, however, likely the result of extensive gene flow among populations. Some loci had significant reductions in nucleotide diversity within inversions compared with interspecies d

SUBMITTER: Schaeffer SW 

PROVIDER: S-EPMC166227 | biostudies-literature | 2003 Jul

REPOSITORIES: biostudies-literature