Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthma.

ABSTRACT:

Background

Research has shown associations between pediatric asthma outcomes and airborne particulate matter (PM). The importance of particle components remains to be determined.

Methods

We followed a panel of 45 schoolchildren with persistent asthma living in Southern California. Subjects were monitored over 10 days with offline fractional exhaled nitric oxide (FeNO), a biomarker of airway inflammation. Personal active sampler exposures included continuous particulate matter < 2.5 microm in aerodynamic diameter (PM2.5), 24-hr PM2.5 elemental and organic carbon (EC, OC), and 24-hr nitrogen dioxide. Ambient exposures included PM2.5, PM2.5 EC and OC, and NO2. Data were analyzed with mixed models controlling for personal temperature, humidity and 10-day period.

Results

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SUBMITTER: Delfino RJ 

PROVIDER: S-EPMC1665398 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature