Molecular epidemiologic evidence for diabetogenic effects of dioxin exposure in U.S. Air force veterans of the Vietnam war.

ABSTRACT:

Background

One of the outcomes positively associated with dioxin exposure in humans is type 2 diabetes.

Objectives

This study was conducted in order to find the molecular biological evidence for the diabetogenic action of dioxin in adipose samples from Vietnam veterans.

Methods

We obtained 313 adipose tissue samples both from Vietnam veterans who were exposed to dioxin (Operation Ranch Hand) and from comparison veterans who served in Southeast Asia with no record of dioxin exposure. We conducted quantitative reverse-transcribed polymerase chain reaction studies on selected marker mRNAs from these samples.

Results

We found the most sensitive and reliable molecular indicator of dioxin-induced diabetes to be the ratio of mRNA of glucose transporter 4 (GLUT4) and n

SUBMITTER: Fujiyoshi PT 

PROVIDER: S-EPMC1665440 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature