Molecular modeling and characterization of Vibrio cholerae transcription regulator HlyU.

ABSTRACT:

Background

The SmtB/ArsR family of prokaryotic metal-regulatory transcriptional repressors represses the expression of operons linked to stress-inducing concentrations of heavy metal ions, while derepression results from direct binding of metal ions by these 'metal-sensor' proteins. The HlyU protein from Vibrio cholerae is the positive regulator of haemolysin gene, it also plays important role in the regulation of expression of the virulence genes. Despite the understanding of biochemical properties, its structure and relationship to other protein families remain unknown.

Results

We find that HlyU exhibits structural features common to the SmtB/ArsR family of transcriptional repressors. Analysis of the modeled structure of HlyU reveals that it does not have the key metal-sen

SUBMITTER: Saha RP 

PROVIDER: S-EPMC1665450 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature