Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.

ABSTRACT:

Background

Protein degradation by the ubiquitin system plays a crucial role in numerous cellular signaling pathways. Deubiquitination, a reversal of ubiquitination, has been recognized as an important regulatory step in the ubiquitin-dependent degradation pathway.

Results

While identifying putative ubiquitin specific protease (USP) enzymes that contain a conserved Asp (I) domain in humans, 4 USP17 subfamily members, highly homologous to DUB-3, have been found (USP17K, USP17L, USP17M, and USP17N), from human chorionic villi. Expression analysis showed that USP17 transcripts are highly expressed in the heart, liver, and pancreas and are expressed moderately in various human cancerous cell lines. Amino acid sequence analysis revealed that they contain the highly conserved Cys,

SUBMITTER: Shin JM 

PROVIDER: S-EPMC1665497 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature