Identification of alternative 5'/3' splice sites based on the mechanism of splice site competition.

ABSTRACT: Alternative splicing plays an important role in regulating gene expression. Currently, most efficient methods use expressed sequence tags or microarray analysis for large-scale detection of alternative splicing. However, it is difficult to detect all alternative splice events with them because of their inherent limitations. Previous computational methods for alternative splicing prediction could only predict particular kinds of alternative splice events. Thus, it would be highly desirable to predict alternative 5'/3' splice sites with various splicing levels using genomic sequences alone. Here, we introduce the competition mechanism of splice sites selection into alternative splice site prediction. This approach allows us to predict not only rarely used but also frequently used alternative

SUBMITTER: Xia H 

PROVIDER: S-EPMC1669764 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature