Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis.

ABSTRACT:

Background

Little is known at the molecular level concerning the differences and/or similarities between alcohol and hepatitis C virus induced liver disease. Global transcriptional profiling using oligonucleotide microarrays was therefore performed on liver biopsies from patients with cirrhosis caused by either chronic alcohol consumption or chronic hepatitis C virus (HCV).

Results

Global gene expression patterns varied significantly depending upon etiology of liver disease, with a greater number of differentially regulated genes seen in HCV-infected patients. Many of the gene expression changes specifically observed in HCV-infected cirrhotic livers were expectedly associated with activation of the innate antiviral immune response. We also compared severity (CTP class) of ci

SUBMITTER: Lederer SL 

PROVIDER: S-EPMC1676004 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature