The homeobox transcription factor Even-skipped regulates acquisition of electrical properties in Drosophila neurons.

ABSTRACT:

Background

While developmental processes such as axon pathfinding and synapse formation have been characterized in detail, comparatively less is known of the intrinsic developmental mechanisms that regulate transcription of ion channel genes in embryonic neurons. Early decisions, including motoneuron axon targeting, are orchestrated by a cohort of transcription factors that act together in a combinatorial manner. These transcription factors include Even-skipped (Eve), islet and Lim3. The perdurance of these factors in late embryonic neurons is, however, indicative that they might also regulate additional aspects of neuron development, including the acquisition of electrical properties.

Results

To test the hypothesis that a combinatorial code transcription factor is also able

SUBMITTER: Pym EC 

PROVIDER: S-EPMC1679800 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature