Ab initio genotype-phenotype association reveals intrinsic modularity in genetic networks.

ABSTRACT: Microbial species express an astonishing diversity of phenotypic traits, behaviors, and metabolic capacities. However, our molecular understanding of these phenotypes is based almost entirely on studies in a handful of model organisms that together represent only a small fraction of this phenotypic diversity. Furthermore, many microbial species are not amenable to traditional laboratory analysis because of their exotic lifestyles and/or lack of suitable molecular genetic techniques. As an adjunct to experimental analysis, we have developed a computational information-theoretic framework that produces high-confidence gene-phenotype predictions using cross-species distributions of genes and phenotypes across 202 fully sequenced archaea and eubacteria. In addition to identifying the genetic b

SUBMITTER: Slonim N 

PROVIDER: S-EPMC1681479 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature