Dynamic analysis of optimality in myocardial energy metabolism under normal and ischemic conditions.

ABSTRACT: To better understand the dynamic regulation of optimality in metabolic networks under perturbed conditions, we reconstruct the energetic-metabolic network in mammalian myocardia using dynamic flux balance analysis (DFBA). Additionally, we modified the optimal objective from the maximization of ATP production to the minimal fluctuation of the profile of metabolite concentration under ischemic conditions, extending the hypothesis of original minimization of metabolic adjustment to create a composite modeling approach called M-DFBA. The simulation results are more consistent with experimental data than are those of the DFBA model, particularly the retentive predominant contribution of fatty acid to oxidative ATP synthesis, the exact mechanism of which has not been elucidated and seems to be u

SUBMITTER: Luo RY 

PROVIDER: S-EPMC1681503 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature