An integrated systems approach for understanding cellular responses to gamma radiation.

ABSTRACT: Cellular response to stress entails complex mRNA and protein abundance changes, which translate into physiological adjustments to maintain homeostasis as well as to repair and minimize damage to cellular components. We have characterized the response of the halophilic archaeon Halobacterium salinarum NRC-1 to (60)Co ionizing gamma radiation in an effort to understand the correlation between genetic information processing and physiological change. The physiological response model we have constructed is based on integrated analysis of temporal changes in global mRNA and protein abundance along with protein-DNA interactions and evolutionarily conserved functional associations. This systems view reveals cooperation among several cellular processes including DNA repair, increased protein turnov

SUBMITTER: Whitehead K 

PROVIDER: S-EPMC1681521 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature