A novel computational model of the circadian clock in Arabidopsis that incorporates PRR7 and PRR9.

ABSTRACT: In plants, as in animals, the core mechanism to retain rhythmic gene expression relies on the interaction of multiple feedback loops. In recent years, molecular genetic techniques have revealed a complex network of clock components in Arabidopsis. To gain insight into the dynamics of these interactions, new components need to be integrated into the mathematical model of the plant clock. Our approach accelerates the iterative process of model identification, to incorporate new components, and to systematically test different proposed structural hypotheses. Recent studies indicate that the pseudo-response regulators PRR7 and PRR9 play a key role in the core clock of Arabidopsis. We incorporate PRR7 and PRR9 into an existing model involving the transcription factors TIMING OF CAB (TOC1), LATE

SUBMITTER: Zeilinger MN 

PROVIDER: S-EPMC1682023 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature