A bifunctional O-GlcNAc transferase governs flagellar motility through anti-repression.

ABSTRACT: Flagellar motility is an essential mechanism by which bacteria adapt to and survive in diverse environments. Although flagella confer an advantage to many bacterial pathogens for colonization during infection, bacterial flagellins also stimulate host innate immune responses. Consequently, many bacterial pathogens down-regulate flagella production following initial infection. Listeria monocytogenes is a facultative intracellular pathogen that represses transcription of flagellar motility genes at physiological temperatures (37 degrees C and above). Temperature-dependent expression of flagellar motility genes is mediated by the opposing activities of MogR, a DNA-binding transcriptional repressor, and DegU, a response regulator that functions as an indirect antagonist of MogR. In this study,

SUBMITTER: Shen A 

PROVIDER: S-EPMC1686605 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature