PromH: Promoters identification using orthologous genomic sequences.

ABSTRACT: Accurate prediction of promoters is fundamental for understanding gene expression patterns, cell specificity and development. In the studies of conserved features of regulatory regions of orthologous genes, it was observed that major promoter functional components such as transcription start points, TATA-boxes and regulatory motifs, are significantly more conservative than the sequences around them (70-100% compared with 30-50%). To improve promoter identification accuracy, we employed these findings in a new program, PromH, created by extending the TSSW program feature set. PromH uses linear discriminant functions that take into account conservation features and nucleotide sequences of promoter regions in pairs of orthologous genes. The program was tested on two sets of pairs of orthologo

SUBMITTER: Solovyev VV 

PROVIDER: S-EPMC168932 | biostudies-literature | 2003 Jul

REPOSITORIES: biostudies-literature