NCI: A server to identify non-canonical interactions in protein structures.

ABSTRACT: NCI is a server for the identification of non-canonical interactions in protein structures. These interactions, which include N-H...pi, C(alpha)-H...pi, C(alpha)-H...O=C and variants of them, were first observed in small molecules and subsequently in high-resolution protein structures. Such interactions have been subjected to extensive structural analysis to elucidate the different geometric criteria required to identify them. These interactions have also recently been shown to be important for the stability of protein structures. In this work, I describe a server called NCI, which allows the user to either upload protein/peptide coordinates in Protein Data Bank (PDB) format or enter a Structural Classification of Proteins database (SCOP)/PDB identifier for which NCI identifies the differe

SUBMITTER: Babu MM 

PROVIDER: S-EPMC168935 | biostudies-literature | 2003 Jul

REPOSITORIES: biostudies-literature