Prediction of lipid posttranslational modifications and localization signals from protein sequences: big-Pi, NMT and PTS1.

ABSTRACT: Many posttranslational modifications (N-myristoylation or glycosylphosphatidylinositol (GPI) lipid anchoring) and localization signals (the peroxisomal targeting signal PTS1) are encoded in short, partly compositionally biased regions at the N- or C-terminus of the protein sequence. These sequence signals are not well defined in terms of amino acid type preferences but they have significant interpositional correlations. Although the number of verified protein examples is small, the quantification of several physical conditions necessary for productive protein binding with the enzyme complexes executing the respective transformations can lead to predictors that recognize the signals from the amino acid sequence of queries alone. Taxon-specific prediction functions are required due to the di

SUBMITTER: Eisenhaber F 

PROVIDER: S-EPMC168944 | biostudies-literature | 2003 Jul

REPOSITORIES: biostudies-literature