WebFEATURE: An interactive web tool for identifying and visualizing functional sites on macromolecular structures.

ABSTRACT: WebFEATURE (http://feature.stanford.edu/webfeature/) is a web-accessible structural analysis tool that allows users to scan query structures for functional sites in both proteins and nucleic acids. WebFEATURE is the public interface to the scanning algorithm of the FEATURE package, a supervised learning algorithm for creating and identifying 3D, physicochemical motifs in molecular structures. Given an input structure or Protein Data Bank identifier (PDB ID), and a statistical model of a functional site, WebFEATURE will return rank-scored 'hits' in 3D space that identify regions in the structure where similar distributions of physicochemical properties occur relative to the site model. Users can visualize and interactively manipulate scored hits and the query structure in web browsers that

SUBMITTER: Liang MP 

PROVIDER: S-EPMC168960 | biostudies-literature | 2003 Jul

REPOSITORIES: biostudies-literature