Geno2pheno: Estimating phenotypic drug resistance from HIV-1 genotypes.

ABSTRACT: Therapeutic success of anti-HIV therapies is limited by the development of drug resistant viruses. These genetic variants display complex mutational patterns in their pol gene, which codes for protease and reverse transcriptase, the molecular targets of current antiretroviral therapy. Genotypic resistance testing depends on the ability to interpret such sequence data, whereas phenotypic resistance testing directly measures relative in vitro susceptibility to a drug. From a set of 650 matched genotype-phenotype pairs we construct regression models for the prediction of phenotypic drug resistance from genotypes. Since the range of resistance factors varies considerably between different drugs, two scoring functions are derived from different sets of predicted phenotypes. Firstly, we compare

SUBMITTER: Beerenwinkel N 

PROVIDER: S-EPMC168981 | biostudies-literature | 2003 Jul

REPOSITORIES: biostudies-literature