Biological context networks: a mosaic view of the interactome.

ABSTRACT: Network models are a fundamental tool for the visualization and analysis of molecular interactions occurring in biological systems. While broadly illuminating the molecular machinery of the cell, graphical representations of protein interaction networks mask complex patterns of interaction that depend on temporal, spatial, or condition-specific contexts. In this paper, we introduce a novel graph construct called a biological context network that explicitly captures these changing patterns of interaction from one biological context to another. We consider known gene ontology biological process and cellular component annotations as a proxy for context, and show that aggregating small process-specific protein interaction sub-networks leads to the emergence of observed scale-free properties. T

SUBMITTER: Rachlin J 

PROVIDER: S-EPMC1693461 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature