Roles for cell wall glycopeptidolipid in surface adherence and planktonic dispersal of Mycobacterium avium.

ABSTRACT: The opportunistic pathogen Mycobacterium avium is a significant inhabitant of biofilms in drinking water distribution systems. M. avium expresses on its cell surface serovar-specific glycopeptidolipids (ssGPLs). Studies have implicated the core GPL in biofilm formation by M. avium and by other Mycobacterium species. In order to test this hypothesis in a directed fashion, three model systems were used to examine biofilm formation by mutants of M. avium with transposon insertions into pstAB (also known as nrp and mps). pstAB encodes the nonribosomal peptide synthetase that catalyzes the synthesis of the core GPL. The mutants did not adhere to polyvinyl chloride plates; however, they adhered well to plastic and glass chamber slide surfaces, albeit with different morphologies from the parent s

SUBMITTER: Freeman R 

PROVIDER: S-EPMC1694245 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature