A naturally occurring novel allele of Escherichia coli outer membrane protein A reduces sensitivity to bacteriophage.

ABSTRACT: A novel Escherichia coli outer membrane protein A (OmpA) was discovered through a proteomic investigation of cell surface proteins. DNA polymorphisms were localized to regions encoding the protein's surface-exposed loops which are known phage receptor sites. Bacteriophage sensitivity testing indicated an association between bacteriophage resistance and isolates having the novel ompA allele.

SUBMITTER: Power ML 

PROVIDER: S-EPMC1694255 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature