Candida albicans transcription factor Ace2 regulates metabolism and is required for filamentation in hypoxic conditions.

ABSTRACT: Ace2 transcription factor family genes are found in many fungal genomes and are required for regulation of expression of genes involved in cell separation. We used transcriptional profiling to identify the targets of Ace2 in Candida albicans, and we show that these include several cell wall components, such as glucanases and glycosylphosphatidylinositol-anchored proteins. Expression is downregulated in ace2 deletion mutants in both yeast and hyphal cells. In addition, deleting ace2 results in dramatic changes in expression of metabolic pathways. Expression of glycolytic enzymes is reduced, while expression of respiratory genes (including those involved in the tricarboxylic acid cycle, oxidative phosphorylation, and ATP synthesis) is increased. Similar changes occur in both yeast and hyphal

SUBMITTER: Mulhern SM 

PROVIDER: S-EPMC1694816 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature