A gene expression signature associated with survival in metastatic melanoma.

ABSTRACT:

Background

Current clinical and histopathological criteria used to define the prognosis of melanoma patients are inadequate for accurate prediction of clinical outcome. We investigated whether genome screening by means of high-throughput gene microarray might provide clinically useful information on patient survival.

Methods

Forty-three tumor tissues from 38 patients with stage III and stage IV melanoma were profiled with a 17,500 element cDNA microarray. Expression data were analyzed using significance analysis of microarrays (SAM) to identify genes associated with patient survival, and supervised principal components (SPC) to determine survival prediction.

Results

SAM analysis revealed a set of 80 probes, corresponding to 70 genes, associated with survival, i.e. 45

SUBMITTER: Mandruzzato S 

PROVIDER: S-EPMC1697826 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature