Global map of growth-regulated gene expression in Burkholderia pseudomallei, the causative agent of melioidosis.

ABSTRACT: Many microbial pathogens express specific virulence traits at distinct growth phases. To understand the molecular pathways linking bacterial growth to pathogenicity, we have characterized the growth transcriptome of Burkholderia pseudomallei, the causative agent of melioidosis. Using a fine-scale sampling approach, we found approximately 17% of all B. pseudomallei genes displaying regulated expression during growth in rich medium, occurring as broad waves of functionally coherent gene expression tightly associated with distinct growth phases and transition points. We observed regulation of virulence genes across all growth phases and identified serC as a potentially new virulence factor by virtue of its coexpression with other early-phase virulence genes. serC-disrupted B. pseudomallei str

SUBMITTER: Rodrigues F 

PROVIDER: S-EPMC1698202 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature