INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families.

ABSTRACT:

Background

Obesity is a major public health problem. Body mass index (BMI) is a highly heritable phenotype but robust associations of genetic polymorphisms to BMI or other obesity-related phenotypes have been difficult to establish. Recently a large genetic association study showed evidence for association of the single nucleotide polymorphism (SNP) rs7566605, which lies 10 Kb 5' to the first exon of the insulin-induced gene 2 (INSIG-2), with obesity in several cohorts. We tested this polymorphism for association with body mass related phenotypes in a large family study whose mean BMI was consistent with moderate overweight.

Methods

We studied 1428 members of 248 British Caucasian families who had been ascertained through a proband with hypertension. We measured BMI, waist a

SUBMITTER: Hall DH 

PROVIDER: S-EPMC1698479 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature