Generalized genomic distance-based regression methodology for multilocus association analysis.

ABSTRACT: Large-scale, multilocus genetic association studies require powerful and appropriate statistical-analysis tools that are designed to relate genotype and haplotype information to phenotypes of interest. Many analysis approaches consider relating allelic, haplotypic, or genotypic information to a trait through use of extensions of traditional analysis techniques, such as contingency-table analysis, regression methods, and analysis-of-variance techniques. In this work, we consider a complementary approach that involves the characterization and measurement of the similarity and dissimilarity of the allelic composition of a set of individuals' diploid genomes at multiple loci in the regions of interest. We describe a regression method that can be used to relate variation in the measure of genom

SUBMITTER: Wessel J 

PROVIDER: S-EPMC1698575 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature