Ontology highlight
ABSTRACT:
SUBMITTER: Schuchmann S
PROVIDER: S-EPMC1698875 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Nature medicine 20060702 7
Febrile seizures are frequent during early childhood, and prolonged (complex) febrile seizures are associated with an increased susceptibility to temporal lobe epilepsy. The pathophysiological consequences of febrile seizures have been extensively studied in rat pups exposed to hyperthermia. The mechanisms that trigger these seizures are unknown, however. A rise in brain pH is known to enhance neuronal excitability. Here we show that hyperthermia causes respiratory alkalosis in the immature brai ...[more]