Large scale study of protein domain distribution in the context of alternative splicing.

ABSTRACT: Alternative splicing plays an important role in processes such as development, differentiation and cancer. With the recent increase in the estimates of the number of human genes that undergo alternative splicing from 5 to 35-59%, it is becoming critical to develop a better understanding of its functional consequences and regulatory mechanisms. We conducted a large scale study of the distribution of protein domains in a curated data set of several thousand genes and identified protein domains disproportionately distributed among alternatively spliced genes. We also identified a number of protein domains that tend to be spliced out. Both the proteins having the disproportionately distributed domains as well as those with spliced-out domains are predominantly involved in the processes of cell

SUBMITTER: Liu S 

PROVIDER: S-EPMC169920 | biostudies-literature | 2003 Aug

REPOSITORIES: biostudies-literature