RNA structure comparison, motif search and discovery using a reduced representation of RNA conformational space.

ABSTRACT: Given the wealth of new RNA structures and the growing list of RNA functions in biology, it is of great interest to understand the repertoire of RNA folding motifs. The ability to identify new and known motifs within novel RNA structures, to compare tertiary structures with one another and to quantify the characteristics of a given RNA motif are major goals in the field of RNA research; however, there are few systematic ways to address these issues. Using a novel approach for visualizing and mathematically describing macromolecular structures, we have developed a means to quantitatively describe RNA molecules in order to rapidly analyze, compare and explore their features. This approach builds on the alternative eta,theta convention for describing RNA torsion angles and is executed using a

SUBMITTER: Duarte CM 

PROVIDER: S-EPMC169959 | biostudies-literature | 2003 Aug

REPOSITORIES: biostudies-literature