Evidence that talin alternative splice variants from Ciona intestinalis have different roles in cell adhesion.

ABSTRACT:

Background

Talins are large, modular cytoskeletal proteins found in animals and amoebozoans such as Dictyostelium discoideum. Since the identification of a second talin gene in vertebrates, it has become increasingly clear that vertebrate Talin1 and Talin2 have non-redundant roles as essential links between integrins and the actin cytoskeleton in distinct plasma membrane-associated adhesion complexes. The conserved C-terminal I/LWEQ module is important for talin function. This structural element mediates the interaction of talins with F-actin. The I/LWEQ module also targets mammalian Talin1 to focal adhesion complexes, which are dynamic multicomponent assemblies required for cell adhesion and cell motility. Although Talin1 is essential for focal adhesion function, Talin2 is not tar

SUBMITTER: Singiser RH 

PROVIDER: S-EPMC1702346 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature