Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.

ABSTRACT:

Background

Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory constraints on kinase activity, can promote malignant transformation, and appear to be a major determinant of response to kinase inhibitor therapy. Missense mutations in the EGFR kinase domain, for example, have recently been identified in patients who showed clinical responses to EGFR kinase inhibitor therapy.

Methods and findings

Encouraged by the promising clinical activity of epidermal growth factor receptor (EGFR) kinase inhibitors in treating glioblastoma in humans, we have sequenced the complete EGFR coding sequence in glioma tumor samples and cell lines. We identified novel m

SUBMITTER: Lee JC 

PROVIDER: S-EPMC1702556 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature