Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is a serious systemic autoimmune disorder that affects multiple organ systems and is characterized by unpredictable flares of disease. Recent evidence indicates a role for type I interferon (IFN) in SLE pathogenesis; however, the downstream effects of IFN pathway activation are not well understood. Here we test the hypothesis that type I IFN-regulated proteins are present in the serum of SLE patients and correlate with disease activity.

Methods and findings

We performed a comprehensive survey of the serologic proteome in human SLE and identified dysregulated levels of 30 cytokines, chemokines, growth factors, and soluble receptors. Particularly striking was the highly coordinated up-regulation of 12 inflammatory and/or homeostati

SUBMITTER: Bauer JW 

PROVIDER: S-EPMC1702557 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature